Manuscript Title:

DEVELOPMENT OF NANO FORMUATION AND ITS OPTIMIZATION EVALUATION OF EFINACONAZOLE LOADED TRANSFERSOMAL GEL FOR TREATMENT OF NAIL INFECTION

Author:

ANJANA DEVI, HIMANSHU CHAURASIA, RANJIT SINGH

DOI Number:

DOI:10.17605/OSF.IO/9P4S6

Published : 2021-11-10

About the author(s)

1. ANJANA DEVI - Research Scholar, Department of Pharmaceutical Sciences, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh – 247341, India.
2. HIMANSHU CHAURASIA - Associate Professor, Department of Pharmaceutical Sciences, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh – 247341, India.
3. RANJIT SINGH - Vice Chancellor, Shobhit University, Saharanpur, Uttar Pradesh – 247341, India.

Full Text : PDF

Abstract

The aim of the study is to formulate Efinaconazole-loaded transfersomes using different proportions of Phospholipon® 90 G and Tween® 80 (95-75: 5-25 percent weight-to-weight) in order to determine the optimal formulation for treatment of nail infection. Each of the transferred vesicles were evaluated for the following characteristics features such as size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, and in vivo skin irritation studies. The results revealed that the formulated transfersomes were negatively charged, had a spherical uni-lamellar structure ranging from 132.97 nm to 553.06 nm in size and had an entrapment efficiency ranging from 40.37 to 84.61 percent. The transdermal flux index of the gel was found to be 0.024±0.002 mg/cm2 /h across the rat skin. It is indicated that the gel formulation was effective in transporting the drugs. Furthermore, in vivo skin irritation studies revealed that the transfersomes prepared were completely free of skin irritation potential (erythema and edema). The present study will aid in understanding the prepared transfersomes with Tween® 80 could be used for improving the transdermal delivery of Efinaconazole in a given formulation. In conclusion, it can be stated that the transdermal transfersomes formulation may have the ability to be a potential drug carrier. The Efinaconazole it is possible to prepare the Efinaconazole treated rats showed good activity and has got proven studies by which it can be scaled up with ease by using the above mentioned factors.


Keywords

Transfersomes, Phospholipon® 90 G, Efinaconazole, Uni-lamellar structure, Transdermal flux.